|
KMID : 1001020160140030109
|
|
Korean Journal of Urological Oncology
2016 Volume.14 No. 3 p.109 ~ p.117
|
|
|
Recombinant Bacille Calmette?Guerin for Immunotherapy in Nonmuscle Invasive Bladder Cancer
|
|
Jin Su-Bin
Whang Young-Mi
Chang In-Ho
|
|
|
Abstract
|
|
|
|
Intravesical instillation of Mycobacterium bovis bacille Calmette?Guerin (BCG) has been used for treating nonmuscle invasive bladder cancer as the forefront of immunotherapy, but BCG is ineffective in approximately 30?40% of cases and disease recurs in up to 50% of patients. Recently BCG is considered an effective vehicle for delivery of antigens due to its unique characteristics, and the genetic control of these mycobacteria is advanced in the search for less toxic and more potent therapeutic agents for bladder cancer immunotherapy. We will discuss current advances in recombinant BCG construction, research, and future directions.
|
|
|
KEYWORD
|
|
|
BCG vaccine, Urinary bladder neoplasms, Immunotherapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|